Paper accepted in Science

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Gabriele‘s paper entitled ‘Multiplexed protein maps link subcellular organization to cellular states’ has been accepted for publication. Congratulations!! This work reports the development of iterative indirect immunofluoresence imaging (4i), which allows 40-plex immunostaining of hundreds of thousands of single cells using conventional primary and secondary antibodies in high-throughput. Combined with cellular computer vision, this generates… Read more »

Paper accepted in Nature

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Arpan‘s paper entitled ‘Kinase-controlled phase transition of membrane-less organelles in mitosis’ has been accepted for publication. Congratulations!! This work shows that the dual-specificity kinase DYRK3 drives the dissolution of membrane-less organelles as cells undergo cell division, and adds to our increasing evidence that DYRK kinases represent a novel class of cellular regulators that control liquid… Read more »

Paper accepted in Molecular Systems Biology

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Reinoud‘s paper entitled ‘Large-scale image-based profiling of single-cell phenotypes in arrayed CRISPR-Cas9 gene perturbation screens’ has been accepted for publication in Molecular Systems Biology. Congratulations!! This now gives us the ability to obtain multivariate quantitative profiles of large numbers of single-cell gene perturbation phenotypes in high-throughput arrayed CRISPR-Cas9-based  screens.

Ola joined the lab!

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On June 4, Ola Sabet joined our lab as a postdoctoral fellow. Ola did her PhD in the laboratory of Philippe Bastiaens at the Max Planck Institute for Molecular Physiology in Dortmund, Germany. In her PhD work, she developed a conformational biosensor of receptor kinase activity in living cells with which she revealed the importance… Read more »

Diego joined the lab!

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On June 1, Diego Villamaina joined our lab as a Big Data and IT specialist. Diego did his PhD at the University of Geneva and his postdoc at the ETH Zurich in Physical Chemistry, during which he became interested in developing computational tools and software for scientific data processing and visualisation. For more details, check here. In… Read more »

Paper in Cell Host&Microbe now online

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The paper by Victoria Green entitled ‘A Systems Survey of Progressive Host-Cell Reorganization during Rotavirus Infection’ is now online in Cell Host & Microbe. Check it out here. This work also comes with an interactive website for browsing through and downloading the data at www.rotavirus.infectome.org.