Doris Popovic‘ work on single-cell relationships between mRNA and protein abundance is now online. Check it out here.
Posts Categorized: News
Doris Berchtold‘s paper entitled ‘A systems-level study reveals regulators of membrane-less organelles in human cells’ is accepted for publication. Congratulations!! This work performed parallel large-scale gene perturbation screens in human cells on 6 membraneless organelles, and applied advanced computer vision and multivariate analyses to quantify effects on the morphology and abundance of these organelles at… Read more »
Doris Popovic‘s paper entitled ‘Multivariate Control of Transcript to Protein Variability in Single Mammalian Cells’ has been accepted for publication. Congratulations!! This work reports that correlations between mRNA and protein abundance of the same gene across thousands of single cells are often quite high, and that single cells that are outliers of such linear correlations are,… Read more »
Gabriele‘s work on developing iterative indirect immunofluorescence imaging (4i) is online. check it out here.
Gabriele has been awarded the UZH BioEntrepreneur-Fellowship based on his project to apply 4i in precision medicine. Congratulations!!
Arpan‘s work on DYRK3 is now online. Check it out here.
Gabriele‘s paper entitled ‘Multiplexed protein maps link subcellular organization to cellular states’ has been accepted for publication. Congratulations!! This work reports the development of iterative indirect immunofluoresence imaging (4i), which allows 40-plex immunostaining of hundreds of thousands of single cells using conventional primary and secondary antibodies in high-throughput. Combined with cellular computer vision, this generates… Read more »
Arpan‘s paper entitled ‘Kinase-controlled phase transition of membrane-less organelles in mitosis’ has been accepted for publication. Congratulations!! This work shows that the dual-specificity kinase DYRK3 drives the dissolution of membrane-less organelles as cells undergo cell division, and adds to our increasing evidence that DYRK kinases represent a novel class of cellular regulators that control liquid… Read more »
Reinoud’s paper is featured on the cover of the January 2018 issue of Molecular Systems Biology.
Reinoud‘s paper entitled ‘Large-scale image-based profiling of single-cell phenotypes in arrayed CRISPR-Cas9 gene perturbation screens’ has been accepted for publication in Molecular Systems Biology. Congratulations!! This now gives us the ability to obtain multivariate quantitative profiles of large numbers of single-cell gene perturbation phenotypes in high-throughput arrayed CRISPR-Cas9-based screens.