A Leading Edge Review on ‘Passive Noise Filtering by Cellular Compartmentalization’, written by Thomas, Nico, and Lucas, appeared today in Cell. Check it out here.
In this review, the principle is presented by which compartmentalization can effectively filter out noise in biological systems, for instance by (short-term) nuclear retention of transcripts, which acts as a highly effective and global buffer of noise in transcription. Research is brought together that indicates that passive noise filtering may be accomplished by multiple different types of cellular compartmentalization, and in different types of biological systems. Finally, the review discusses how noise filtering by cellular compartmentalization may have been involved in the emergence of obligate multicellular organisms during evolution, which are, interestingly, all eukaryotes.