Publications | Pelkmans Lab -

1.

Green, V. A. & Pelkmans, L. A Systems Survey of Progressive Host-Cell Reorganization during Rotavirus Infection. Cell Host & Microbe 20, 107–120 (2016). [Journal] [PDF]

1.

Stoeger, T., Battich, N. & Pelkmans, L. Passive Noise Filtering by Cellular Compartmentalization. Cell 164, 1151–1161 (2016). [Journal] [PDF] [Pubmed]

1.

Battich, N., Stoeger, T. & Pelkmans, L. Control of Transcript Variability in Single Mammalian Cells. Cell 163, 1596–1610 (2015). [Journal] [PDF] [Pubmed]

1.

Stoeger, T., Battich, N., Herrmann, M. D., Yakimovich, Y. & Pelkmans, L. Computer vision for image-based transcriptomics. Methods 85, 44–53 (2015). [Journal] [PDF] [Pubmed]

1.

Gut, G., Tadmor, M. D., Pe’er, D., Pelkmans, L. & Liberali, P. Trajectories of cell-cycle progression from fixed cell populations. Nature Methods 12, 951–954 (2015). [Journal] [PDF] [Pubmed]

1.

Bologna, S. et al. Sumoylation regulates EXO1 stability and processing of DNA damage. Cell Cycle 14, 2439–2450 (2015). [Journal] [PDF] [Pubmed]

1.

Scott, C. C. et al. Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis. EMBO reports 16, 741–752 (2015). [Journal] [PDF] [Pubmed]

1.

Frechin, M. et al. Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour. Nature (2015). doi:10.1038/nature14429 [Journal] [PDF] [Pubmed]

1.

Liberali, P., Snijder, B. & Pelkmans, L. Single-cell and multivariate approaches in genetic perturbation screens. Nature Reviews Genetics (2014). doi:10.1038/nrg3768 [Journal] [PDF] [Pubmed]

1.

Burkard, C. et al. Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner. PLoS Pathogens 10, e1004502 (2014). [Journal] [PDF] [Pubmed]

1.

Liberali, P., Snijder, B. & Pelkmans, L. A Hierarchical Map of Regulatory Genetic Interactions in Membrane Trafficking. Cell 157, 1473–1487 (2014). [Journal] [PDF] [Pubmed]

1.

Aydin, I. et al. Large Scale RNAi Reveals the Requirement of Nuclear Envelope Breakdown for Nuclear Import of Human Papillomaviruses. PLoS Pathogens 10, e1004162 (2014). [Journal] [PDF] [Pubmed]

1.

Franceschini, A. et al. Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens. Proceedings of the National Academy of Sciences 111, 4548–4553 (2014). [Journal] [PDF] [Pubmed]

1.

Rämö, P. et al. Simultaneous analysis of large-scale RNAi screens for pathogen entry. BMC genomics 15, 1 (2014). [Journal] [PDF] [Pubmed]

1.

Battich, N., Stoeger, T. & Pelkmans, L. Image-based transcriptomics in thousands of single human cells at single-molecule resolution. Nature Methods 10, 1127–1133 (2013). [Journal] [PDF] [Pubmed]

1.

Snijder, B., Liberali, P., Frechin, M., Stoeger, T. & Pelkmans, L. Predicting functional gene interactions with the hierarchical interaction score. Nature Methods 10, 1089–1092 (2013). [Journal] [PDF] [Pubmed]

1.

Wippich, F. et al. Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling. Cell 152, 791–805 (2013). [Journal] [PDF] [Pubmed]

1.

Stergiou, L. et al. Integrin-Mediated Signaling Induced by Simian Virus 40 Leads to Transient Uncoupling of Cortical Actin and the Plasma Membrane. PLoS ONE 8, e55799 (2013). [Journal] [PDF] [Pubmed]

1.

Liberali, P. & Pelkmans, L. Towards quantitative cell biology. Nature cell biology 14, 1233–1233 (2012). [Journal] [PDF] [Pubmed]

1.

Mercer, J. et al. RNAi Screening Reveals Proteasome- and Cullin3-Dependent Stages in Vaccinia Virus Infection. Cell Reports 2, 1036–1047 (2012). [Journal] [PDF] [Pubmed]

1.

Pelkmans, L. Using Cell-to-Cell Variability—A New Era in Molecular Biology. Science 336, 425–426 (2012). [Journal] [PDF] [Pubmed]

1.

Snijder, B. et al. Single-cell analysis of population context advances RNAi screening at multiple levels. Molecular Systems Biology 8, (2012). [Journal] [PDF] [Pubmed]

1.

Misselwitz, B. et al. RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. Molecular Systems Biology 7, (2011). [Journal] [PDF] [Pubmed]

1.

Snijder, B. & Pelkmans, L. Origins of regulated cell-to-cell variability. Nature Reviews Molecular Cell Biology 12, 119–125 (2011). [Journal] [PDF] [Pubmed]

1.

Ruusuvuori, P. et al. Evaluation of methods for detection of fluorescence labeled subcellular objects in microscope images. BMC bioinformatics 11, 248 (2010). [Journal] [PDF] [Pubmed]

1.

Ramo, P., Sacher, R., Snijder, B., Begemann, B. & Pelkmans, L. CellClassifier: supervised learning of cellular phenotypes. Bioinformatics 25, 3028–3030 (2009). [Journal] [PDF] [Pubmed]

1.

Snijder, B. et al. Population context determines cell-to-cell variability in endocytosis and virus infection. Nature 461, 520–523 (2009). [Journal] [PDF] [Pubmed]

1.

Pelkmans, L. Systems biology of virus infection in mammalian cells. Current Opinion in Microbiology 12, 429–431 (2009). [Journal] [PDF] [Pubmed]

1.

Short, B. Lucas Pelkmans: Taking it from the top. J Cell Biol 185, 932–933 (2009). [Journal] [PDF]

1.

Aebersold, R. et al. Report on EU–USA Workshop: How Systems Biology Can Advance Cancer Research (27 October 2008). Molecular Oncology 3, 9–17 (2009). [Journal] [PDF] [Pubmed]

1.

Liberali, P., Rämö, P. & Pelkmans, L. Protein Kinases: Starting a Molecular Systems View of Endocytosis. Annual Review of Cell and Developmental Biology 24, 501–523 (2008). [Journal] [PDF] [Pubmed]

1.

Sacher, R., Stergiou, L. & Pelkmans, L. Lessons from genetics: interpreting complex phenotypes in RNAi screens. Current Opinion in Cell Biology 20, 483–489 (2008). [Journal] [PDF] [Pubmed]

1.

Ghigo, E. et al. Ameobal Pathogen Mimivirus Infects Macrophages through Phagocytosis. PLoS Pathogens 4, e1000087 (2008). [Journal] [PDF] [Pubmed]

1.

Schelhaas, M. et al. Simian Virus 40 Depends on ER Protein Folding and Quality Control Factors for Entry into Host Cells. Cell 131, 516–529 (2007). [Journal] [Pubmed]

1.

Bauer, M. & Pelkmans, L. A new paradigm for membrane-organizing and -shaping scaffolds. FEBS Letters 580, 5559–5564 (2006). [Journal] [PDF] [Pubmed]

1.

Damm, E.-M. & Pelkmans, L. Systems biology of virus entry in mammalian cells. Cellular Microbiology 8, 1219–1227 (2006). [Journal] [PDF] [Pubmed]

1.

Pelkmans, L. Secrets of caveolae- and lipid raft-mediated endocytosis revealed by mammalian viruses. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1746, 295–304 (2005). [Journal] [PDF] [Pubmed]

1.

Tagawa, A. Assembly and trafficking of caveolar domains in the cell: caveolae as stable, cargo-triggered, vesicular transporters. The Journal of Cell Biology 170, 769–779 (2005). [Journal] [Pubmed]

1.

Pelkmans, L. & Zerial, M. Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae. Nature 436, 128–133 (2005). [Journal] [PDF]

1.

Pelkmans, L. Viruses as probes for systems analysis of cellular signalling, cytoskeleton reorganization and endocytosis. Current Opinion in Microbiology 8, 331–337 (2005). [Journal] [PDF]

1.

Pelkmans, L. et al. Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Nature 436, 78–86 (2005). [Journal] [PDF]

1.

Damm, E.-M. Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae. The Journal of Cell Biology 168, 477–488 (2005). [Journal] [PDF] [Pubmed]

1.

Pietiäinen, V. et al. Echovirus 1 endocytosis into caveosomes requires lipid rafts, dynamin II, and signaling events. Molecular biology of the cell 15, 4911–4925 (2004). [Journal] [PDF] [Pubmed]

1.

Pelkmans, L., Bürli, T., Zerial, M. & Helenius, A. Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic. Cell 118, 767–780 (2004). [Journal] [PDF] [Pubmed]

1.

Miaczynska, M., Pelkmans, L. & Zerial, M. Not just a sink: endosomes in control of signal transduction. Current Opinion in Cell Biology 16, 400–406 (2004). [Journal] [PDF] [Pubmed]

1.

Pelkmans, L. & Helenius, A. Insider information: what viruses tell us about endocytosis. Current Opinion in Cell Biology 15, 414–422 (2003). [Journal] [PDF] [Pubmed]

1.

Pelkmans, L. Local Actin Polymerization and Dynamin Recruitment in SV40-Induced Internalization of Caveolae. Science 296, 535–539 (2002). [Journal] [PDF] [Pubmed]

1.

Pelkmans, L., Kartenbeck, J. & Helenius, A. Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER. Nature cell biology 3, 473–483 (2001). [Journal] [PDF] [Pubmed]

1.

Nagelkerken, B. et al. Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles. Biochem. J 346, 593–601 (2000). [Journal] [PDF] [Pubmed]

1.

Pelkmans, L. & Helenius, A. Expression of antibody interferes with disulfide bond formation and intracellular transport of antigen in the secretory pathway. Journal of Biological Chemistry 274, 14495–14499 (1999). [Journal] [PDF] [Pubmed]