Reinoud‘s paper entitled ‘Large-scale image-based profiling of single-cell phenotypes in arrayed CRISPR-Cas9 gene perturbation screens’ has been accepted for publication in Molecular Systems Biology. Congratulations!!
This now gives us the ability to obtain multivariate quantitative profiles of large numbers of single-cell gene perturbation phenotypes in high-throughput arrayed CRISPR-Cas9-based screens.
On June 4, Ola Sabet joined our lab as a postdoctoral fellow. Ola did her PhD in the laboratory of Philippe Bastiaens at the Max Planck Institute for Molecular Physiology in Dortmund, Germany. In her PhD work, she developed a conformational biosensor of receptor kinase activity in living cells with which she revealed the importance of quantifying the dynamic and spatial segregation of signalling molecules to understand signaling output. For more details, check here
In our lab, Ola will push the boundaries of temporal and spatial resolution in large-scale image-based systems biology approaches.
On June 1, Diego Villamaina joined our lab as a Big Data and IT specialist. Diego did his PhD at the University of Geneva and his postdoc at the ETH Zurich in Physical Chemistry, during which he became interested in developing computational tools and software for scientific data processing and visualisation. For more details, check here.
In our lab, Diego will be responsible for IT infrastructure and the further development of our computational framework for the interactive visualization and distributed analysis of large-scale microscopy image datasets.
Scott also succeeded to obtain a postdoctoral fellowship from the Human Frontier Science Program. Congratulations!
University of Zurich ranks as the best University in Switzerland in the area of Life Sciences. Source: QS World University Rankings 2017.
Scott succeeded to obtain an EMBO long term fellowship for his postdoctoral work in the lab. Congratulations!
The paper by Victoria Green entitled ‘A Systems Survey of Progressive Host-Cell Reorganization during Rotavirus Infection’ is now online in Cell Host & Microbe. Check it out here.
This work also comes with an interactive website for browsing through and downloading the data at www.rotavirus.infectome.org.
Vicky‘s paper entitled ‘A Systems Survey of Progressive Host Cell Reorganization During Rotavirus Infection’ has been accepted for publication in Cell Host & Microbe. Congratulations!! Check also www.rotavirus.infectome.org.
Doris also succeeded to obtain a postdoctoral fellowship from the Human Frontier Science Program. Congratulations!
A Leading Edge Review on ‘Passive Noise Filtering by Cellular Compartmentalization’, written by Thomas, Nico, and Lucas, appeared today in Cell. Check it out here.
In this review, the principle is presented by which compartmentalization can effectively filter out noise in biological systems, for instance by (short-term) nuclear retention of transcripts, which acts as a highly effective and global buffer of noise in transcription. Research is brought together that indicates that passive noise filtering may be accomplished by multiple different types of cellular compartmentalization, and in different types of biological systems. Finally, the review discusses how noise filtering by cellular compartmentalization may have been involved in the emergence of obligate multicellular organisms during evolution, which are, interestingly, all eukaryotes.