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Reinoud‘s paper entitled ‘Large-scale image-based profiling of single-cell phenotypes in arrayed CRISPR-Cas9 gene perturbation screens’ has been accepted for publication in Molecular Systems Biology. Congratulations!!

This now gives us the ability to obtain multivariate quantitative profiles of large numbers of single-cell gene perturbation phenotypes in high-throughput arrayed CRISPR-Cas9-based  screens.

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On June 4, Ola Sabet joined our lab as a postdoctoral fellow. Ola did her PhD in the laboratory of Philippe Bastiaens at the Max Planck Institute for Molecular Physiology in Dortmund, Germany. In her PhD work, she developed a conformational biosensor of receptor kinase activity in living cells with which she revealed the importance of quantifying the dynamic and spatial segregation of signalling molecules to understand signaling output. For more details, check here

In our lab, Ola will push the boundaries of temporal and spatial resolution in large-scale image-based systems biology approaches.

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On June 1, Diego Villamaina joined our lab as a Big Data and IT specialist. Diego did his PhD at the University of Geneva and his postdoc at the ETH Zurich in Physical Chemistry, during which he became interested in developing computational tools and software for scientific data processing and visualisation. For more details, check here.

In our lab, Diego will be responsible for IT infrastructure and the further development of our computational framework for the interactive visualization and distributed analysis of large-scale microscopy image datasets.

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A Leading Edge Review on ‘Passive Noise Filtering by Cellular Compartmentalization’, written by Thomas, Nico, and Lucas, appeared today in Cell. Check it out here.

In this review, the principle is presented by which compartmentalization can effectively filter out noise in biological systems, for instance by (short-term) nuclear retention of transcripts, which acts as a highly effective and global buffer of noise in transcription. Research is brought together that indicates that passive noise filtering may be accomplished by multiple different types of cellular compartmentalization, and in different types of biological systems. Finally, the review discusses how noise filtering by cellular compartmentalization may have been involved in the emergence of obligate multicellular organisms during evolution, which are, interestingly, all eukaryotes.